New research shows psilocybin, the active ingredient in Magic Mushrooms, to have huge potential for treating depression.

New research shows psilocybin, the active ingredient in Magic Mushrooms, to have huge potential for treating depression.

Depression is a first world problem. Of course, depression exists worldwide, but it’s a huge and growing problem in wealthy, developed countries. As we get richer, we get more and more unhappy, studies show.

Yet despite up to a third of Europeans and 350 million people globally now suffering from depression and the considerable burden this places on health services, mainstream medicine is remarkably ineffective. Just 50% of patients respond to antidepressants, while around 20% do not respond to any treatment.

Now British researchers believe they have discovered the most effective treatment yet: Magic Mushrooms. The Beckley/Imperial Research Programme study, led by Dr Robin Carhart-Harris, gave 12 patients suffering from treatment-resistant depression two separate doses of psilocybin seven days apart, together with psychological support.

A remarkable 67% of patients were depression free one week after treatment, with 42% still in remission three months later, according to findings published in the Lancet Psychiatry. Patients had suffered an average of over 18 years of depression and had found no respite in any other treatment.

Amanda Fielding, founder of the Beckley Foundation, which is pioneering the new wave of psychedelics research, says. “It is very exciting that our latest psilocybin study paves the way for a new treatment for depression. For the first time in many years, people who were at the end of the road with currently available treatments reported decreased anxiety, increased optimism and an ability to enjoy things. This is an unparalleled success and could revolutionise the treatment of depression.”

It is still unclear whether the effects were caused by purely chemical changes within the brain, or whether the psychedelic experience itself, described by participants as ‘mystical’ or ‘spiritual’, helped shift ingrained thought patterns.

This small scale study is just the first step towards developing effective treatment for depression. The initial positive findings would have to be replicated in larger clinical trials before a suitable treatment is available to patients.

Drug controls place significant barriers in the way of further research. In this study, Imperial College London’s Dr. David Nutt, who oversaw the research, estimated the cost of each dosage rose from £30 to £1,500 due to legal hurdles.

Combined with the Beckley/Imperial Research Programme’s groundbreaking study into LSD’s effects on the brain last month, researchers are confident that a growing weight of evidence into potential benefits will overcome resistance in the medical establishment. Taken together, the initial findings support how changes in consciousness induced by psychedelics could become invaluable tools for psychiatry and psychotherapy.

Find out more about The Beckley/Imperial Research Programme’s psilocybin study.

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